1. Struggle with
强调持续的努力和困难。
例：She struggles with math.（她在数学上有困难）
2. Have difficulty/trouble with
通用表达，直接替换。
例：He has trouble with pronunciation.（他发音有问题）
3. Face challenges with
较正式，暗示需要克服的障碍。
例：The team faces challenges with the new software.（团队在新软件上遇到挑战）
4. Grapple with
强调努力解决问题，较正式。
例：Scientists grapple with climate change.（科学家努力应对气候变化）
5. Have a hard time with
口语化，表达费力或挫败感。
例：I have a hard time with early mornings.（我早起很困难）
6. Take issue with
用于表达不同意见（非指困难）。
例：I take issue with his approach.（我对他的方法有意见）
其他选项：
Encounter issues with（中性，指遇到问题）
Find it difficult to（需接动词原形，例：find it difficult to focus）
Deal with problems in（侧重处理过程）
根据语境选择：
学习困难 → struggle with / have trouble with
正式场景 → face challenges / grapple with
表达不满 → take issue with
